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  1. The aim of this study was to investigate the relationship between multiple metabolism parameters derived from FDG and tumor TNM stages as well as tumor metastasis-associated protein of GLUT-1 and MACC1 in colo...

    Authors: Mingyu Zhang, Jigang Yang, Hao Jiang, Huijie Jiang and Zhenchang Wang

    Citation: BMC Cancer 2021 21:258

    Content type: Research article

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  2. Lung adenocarcinoma (LUAD) is the most frequently diagnosed histological subtype of lung cancer. Our purpose was to explore molecular subtypes and core genes for LUAD using multi-omics analysis.

    Authors: Yue Zhao, Yakun Gao, Xiaodong Xu, Jiwu Zhou and He Wang

    Citation: BMC Cancer 2021 21:257

    Content type: Research article

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  3. Head and neck cancers are aggressive cancers, most clinical studies focused on the prognosis of patients with head and neck cancer. However, perioperative mortality was rarely mentioned.

    Authors: Yannan Wang, Mengxue Wang, Yan Tang, Bincan Sun, Kai Wang and Feiya Zhu

    Citation: BMC Cancer 2021 21:256

    Content type: Research article

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  4. Competing endogenous RNA (ceRNA) represents a class of RNAs (e.g., long noncoding RNAs [lncRNAs]) with microRNA (miRNA) binding sites, which can competitively bind miRNA and inhibit its regulation of target ge...

    Authors: Jingyi Chen, Yuxuan Song, Mei Li, Yu Zhang, Tingru Lin, Jie Sun, Di Wang, Yulan Liu, Jingzhu Guo and Weidong Yu

    Citation: BMC Cancer 2021 21:255

    Content type: Research article

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  5. Alcohol consumption is a major risk factor for esophageal cancer; however, a high incidence of esophageal cancer is observed particularly among Eastern Asians, although they consume relatively less alcohol, pr...

    Authors: Chang Kyun Choi, Jungho Yang, Sun-Seog Kweon, Sang-Hee Cho, Hye-Yeon Kim, Eun Myung and Min-Ho Shin

    Citation: BMC Cancer 2021 21:254

    Content type: Research article

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  6. The liver is one of the most frequent sites of metastases in rectal cancer. This study aimed to evaluate how the development of synchronous or metachronous liver metastasis and overall survival are impacted by...

    Authors: Giulia Besutti, Angela Damato, Francesco Venturelli, Candida Bonelli, Massimo Vicentini, Filippo Monelli, Pamela Mancuso, Guido Ligabue, Pierpaolo Pattacini, Carmine Pinto and Paolo Giorgi Rossi

    Citation: BMC Cancer 2021 21:253

    Content type: Research article

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  8. We quantified the elusive effects of putative factors on the clinical course of early hepatocellular carcinoma (HCC) after primary surgical or nonsurgical curative treatment.

    Authors: Ming-Jeng Kuo, Lein-Ray Mo and Chi-Ling Chen

    Citation: BMC Cancer 2021 21:250

    Content type: Research article

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  9. The current standard postoperative treatment for stage II-IIIA non-small cell lung cancer (NSCLC) is a regimen of platinum doublet adjuvant chemotherapy. These regimens, which are the same as for solid NSCLC t...

    Authors: Tomoshi Tsuchiya, Keitaro Matsumoto, Takuro Miyazaki, Ryoichiro Doi, Shoji Tokunaga, Hiroyuki Yamaguchi, Koichi Tomoshige, Hironosuke Watanabe, Takeshi Nagayasu and Kenji Sugio

    Citation: BMC Cancer 2021 21:249

    Content type: Study protocol

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  10. Low-grade glioma (LGG) is a relatively rare type of brain tumour. The use of antidepressant, sedative and anti-epileptic drugs can reflect the burden of the disease. While epilepsy is well-described in patient...

    Authors: Isabelle Rydén, Erik Thurin, Louise Carstam, Anja Smits, Sasha Gulati, Roger Henriksson, Øyvind Salvesen and Asgeir Store Jakola

    Citation: BMC Cancer 2021 21:248

    Content type: Research article

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  12. Alpha-fetoprotein-negative hepatocellular carcinoma (AFP-NHCC) (< 8.78 ng/mL) have special clinicopathologic characteristics and prognosis. The aim of this study was to apply a new method to establish and vali...

    Authors: Dongdong Zhou, Xiaoli Liu, Xinhui Wang, Fengna Yan, Peng Wang, Huiwen Yan, Yuyong Jiang and Zhiyun Yang

    Citation: BMC Cancer 2021 21:246

    Content type: Research article

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  13. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Dearbhaile Catherine Collins, Raghav Sundar, Anastasia Constantinidou, David Dolling, Timothy Anthony Yap, Sanjay Popat, Mary E. O’Brien, Udai Banerji, Johann Sebastian de Bono, Juanita Suzanne Lopez, Nina Tunariu and Anna Minchom

    Citation: BMC Cancer 2021 21:245

    Content type: Correction

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    The original article was published in BMC Cancer 2020 20:1210

  15. It is very important to accurately delineate the CTV on the patient’s three-dimensional CT image in the radiotherapy process. Limited to the scarcity of clinical samples and the difficulty of automatic delinea...

    Authors: Zhongjian Ju, Wen Guo, Shanshan Gu, Jin Zhou, Wei Yang, Xiaohu Cong, Xiangkun Dai, Hong Quan, Jie Liu, Baolin Qu and Guocai Liu

    Citation: BMC Cancer 2021 21:243

    Content type: Research article

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  16. The survival rates of advanced cancer patients remain low despite clinical therapy advancements. However, physical activity showed promising effects in improving cancer outcomes. This review aimed to systemati...

    Authors: Naomi Takemura, Siu Ling Chan, Robert Smith, Denise Shuk Ting Cheung and Chia-Chin Lin

    Citation: BMC Cancer 2021 21:242

    Content type: Research article

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  18. Genetic alterations have been proven to be the promising biomarkers for ICI response. However, sex biases in genetic alterations have been often ignored in the field of immunotherapy, which might specially inf...

    Authors: You Ge, Feiran Wei, Guoping Du, Gaoqiang Fei, Wei Li, Xiaoshan Li, Jinjin Chu and Pingmin Wei

    Citation: BMC Cancer 2021 21:240

    Content type: Research article

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  19. Cancer-associated fibroblasts (CAFs) are some of the most abundant components of the tumour microenvironment. A recent study suggested that in some cancers, CAFs express programmed death ligand 1 (PD-L1), whic...

    Authors: Katsuhiro Yoshikawa, Mitsuaki Ishida, Hirotsugu Yanai, Koji Tsuta, Mitsugu Sekimoto and Tomoharu Sugie

    Citation: BMC Cancer 2021 21:239

    Content type: Research article

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  20. Liver metastasis is a significant adverse predictor of overall survival (OS) among breast cancer patients. The purpose of this study was to determine the risk and prognostic factors of breast cancer with liver...

    Authors: Lei Ji, Lei Cheng, Xiuzhi Zhu, Yu Gao, Lei Fan and Zhonghua Wang

    Citation: BMC Cancer 2021 21:238

    Content type: Research article

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  22. Chemotherapy-induced peripheral neuropathy (CIPN) negatively affects physical function and chemotherapy dosing, yet, clinicians infrequently document CIPN assessment and/or adhere to evidence-based CIPN manage...

    Authors: Robert Knoerl, Emanuele Mazzola, Fangxin Hong, Elahe Salehi, Nadine McCleary, Jennifer Ligibel, Kaitlen Reyes and Donna L. Berry

    Citation: BMC Cancer 2021 21:236

    Content type: Research article

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  23. Recent studies have shown that mixed predominantly differentiated-type (MD) early gastric cancer (EGC) might have more malignant potential than pure differentiated-type (PD) EGC. However, no study has analyzed...

    Authors: Yutaka Okagawa, Tetsuya Sumiyoshi, Hitoshi Kondo, Yusuke Tomita, Takeshi Uozumi, Reiichi Iida, Hiroya Sakano, Kaho Tokuchi, Takashi Jin, Masahiro Yoshida, Akira Sakurada, Ryoji Fujii, Takeyoshi Minagawa, Kohtaro Morita, Kei Yane, Hideyuki Ihara…

    Citation: BMC Cancer 2021 21:235

    Content type: Research article

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  24. Neuroendocrine tumours (NETs) arise from hormone-producing or nervous system cells and can develop from anywhere in the body. They have heterogeneous origins from skin to gastrointestinal track and a complicat...

    Authors: Guney Isa Burak, Sonmezler Ozge, Mujde Cem, Buyukdereli Gulgun, Dogruca Yapar Zeynep and Bisgin Atil

    Citation: BMC Cancer 2021 21:234

    Content type: Research article

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  25. It was demonstrated that multifunctional protein APE1 (Apurinic/apyrimidinic endonuclease 1) is closely related to tumor immune microenvironment in a number of investigations, Meanwhile, the abundance of tumor...

    Authors: Yanping Li, Xiaolong Zhao, He Xiao, Bo Yang, Jie Liu, Wen Rao, Xiaoyan Dai, Mengxia Li, Nan Dai, Yuxin Yang and Dong Wang

    Citation: BMC Cancer 2021 21:233

    Content type: Research article

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  26. There is currently a lack of information on full anogenital evaluation of women with a previous history of anogenital neoplasia.

    Authors: Andreia Albuquerque, Michelle A. L. Godfrey, Carmelina Cappello, Francesca Pesola, Julie Bowring, Tamzin Cuming, Anke De Masi, Adam N. Rosenthal, Peter Sasieni and Mayura Nathan

    Citation: BMC Cancer 2021 21:232

    Content type: Research article

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  27. Taking patient centeredness into account is important in healthcare. The European Cancer Consumer Quality Index (ECCQI) is a validated tool for international benchmarking of patient experiences and satisfaction.

    Authors: A. Wind, E. D. Hartman, R. R. J. P. Van Eekeren, R. P. W. F. Wijn, J. Halámková, J. Mattson, S. Siesling and W. H. van Harten

    Citation: BMC Cancer 2021 21:231

    Content type: Research article

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  28. AURA study reported 61% objective response rate and progression-free survival of 9.6 months with osimertinib in patients with EGFR/T790M+ non-small cell lung cancer. Due to lack of real-world data, we proposed...

    Authors: Mariano Provencio, Josefa Terrasa, Pilar Garrido, Rosario García Campelo, Francisco Aparisi, Pilar Diz, David Aguiar, Carlos García-Giron, Julia Hidalgo, Carlos Aguado, Jorge García González, Emilio Esteban, Lorenzo Gómez-Aldavarí, Teresa Moran, Oscar Juan, Luís Enrique Chara…

    Citation: BMC Cancer 2021 21:230

    Content type: Research article

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  29. A recent study found an influence of organized mammography screening programmes (MSPs) on geographical and temporal variation of mastectomy rates. We aimed to quantify the effect on the example of one of the c...

    Authors: Christian Herrmann, Rudolf Morant, Esther Walser, Mohsen Mousavi and Beat Thürlimann

    Citation: BMC Cancer 2021 21:229

    Content type: Research article

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  30. Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is an important cancer stem cell marker in gastric cancer. However, no detailed studies are available on LGR5 expression in poorly differentiated...

    Authors: Takehito Ehara, Takeshi Uehara, Tomoyuki Nakajima, Yasuhiro Kinugawa, Shota Kobayashi, Mai Iwaya, Hiroyoshi Ota and Yuji Soejima

    Citation: BMC Cancer 2021 21:228

    Content type: Research article

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  31. Although myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN) – including chronic myeloid leukemia (CML) – and myelodysplastic/myeloproliferative neoplasms (MDS/MPN)...

    Authors: K. A. Mundt, L. D. Dell, P. Boffetta, E. M. Beckett, H. N. Lynch, V. J. Desai, C. K. Lin and W. J. Thompson

    Citation: BMC Cancer 2021 21:227

    Content type: Review

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  32. Despite the proportion of elderly breast cancer patients has been consistently increasing, the optimal treatment modalities for this population have not been well explored. We summarized the treatment outcomes...

    Authors: Xu Liu, Dan Zheng, Yanqi Wu, Chuanxu Luo, Yu Fan, Xiaorong Zhong and Hong Zheng

    Citation: BMC Cancer 2021 21:226

    Content type: Research article

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  34. Cervical cancer is preventable and remains a leading cause of avoidable death among women in the world. In a developing country, the knowledge of screening for cervical cancer behavior still very low. However,...

    Authors: Tiruneh Ararsa, Niguse Tadele, Yohannes Ayalew and Debela Gela

    Citation: BMC Cancer 2021 21:224

    Content type: Research article

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  35. Due to recent concerns about the toxicity of trastuzumab emtansine (T-DM1) with stereotactic radiation, we assessed our institutional outcomes treating HER2-positive breast cancer brain metastases (BCBM) with T-D...

    Authors: Matthew N. Mills, Chelsea Walker, Chetna Thawani, Afrin Naz, Nicholas B. Figura, Sergiy Kushchayev, Arnold Etame, Hsiang-Hsuan Michael Yu, Timothy J. Robinson, James Liu, Michael A. Vogelbaum, Peter A. Forsyth, Brian J. Czerniecki, Hatem H. Soliman, Hyo S. Han and Kamran A. Ahmed

    Citation: BMC Cancer 2021 21:223

    Content type: Research article

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  36. The role of surgery for the primary tumor in breast cancer patients with bone metastases (BM) remains unclear. The purpose of this study was to determine the impact of surgery for the primary tumor in breast c...

    Authors: Zhangheng Huang, Xin Zhou, Yuexin Tong, Lujian Zhu, Ruhan Zhao and Xiaohui Huang

    Citation: BMC Cancer 2021 21:222

    Content type: Research article

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  37. Predicting the possibility of ipsilateral lateral cervical lymph node metastasis (ipsi-LLNM) was crucial to the operation plan for patients with papillary thyroid carcinoma (PTC). This study aimed to investiga...

    Authors: Ying Zou, Huanlei Zhang, Wenfei Li, Yu Guo, Fang Sun, Yan Shi, Yan Gong, Xiudi Lu, Wei Wang and Shuang Xia

    Citation: BMC Cancer 2021 21:221

    Content type: Research article

    Published on:

  38. High grade serous ovarian cancer (HGSOC) accounts for nearly 60% of total cases of epithelial ovarian cancer. It is the most aggressive subtype, which shows poor prognosis and low patient survival. For better ...

    Authors: Rachel Topno, Ibha Singh, Manoj Kumar and Pallavi Agarwal

    Citation: BMC Cancer 2021 21:220

    Content type: Research article

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  39. The question whether lymphocyte radiosensitivity is representative of patients’ response to radiotherapy (RT) remains unsolved. We analyzed lymphocyte cytogenetic damage in patients who were homogeneously trea...

    Authors: Leif Hendrik Dröge, Steffen Hennies, Stephan Lorenzen, Lena-Christin Conradi, Henriette Quack, Torsten Liersch, Christian Helms, Miriam Alice Frank, Markus Anton Schirmer, Margret Rave-Fränk, Tim Beißbarth and Hendrik Andreas Wolff

    Citation: BMC Cancer 2021 21:219

    Content type: Research article

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  40. In Korea, where gastric cancer is highly prevalent, biennial endoscopy is recommended among individuals over 40. Even under regular screening, some are still diagnosed at advanced stages. We aimed to identify ...

    Authors: Joo Hyun Lim, Ji Hyun Song, Su Jin Chung, Goh Eun Chung and Joo Sung Kim

    Citation: BMC Cancer 2021 21:218

    Content type: Research article

    Published on:

  41. Certain sequences of genomic mutations can lead to cancer formation and affect treatment outcomes and drug resistance. We constructed a cancer evolutionary tree using bulk-targeted deep sequencing to explore t...

    Authors: Peng-Chan Lin, Yu-Min Yeh, Ren-Hao Chan, Bo-Wen Lin, Po-Chuan Chen, Chien-Chang Pan and Meng-Ru Shen

    Citation: BMC Cancer 2021 21:217

    Content type: Research article

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  42. HIPEC is an emerging procedure to treat peritoneal metastasis of gastric cancer. Data about HIPEC in locally advanced gastric cancer is scarce. The purpose of this trial is to evaluate the safety and toxicity ...

    Authors: Biao Fan, Zhaode Bu, Ji Zhang, Xianglong Zong, Xin Ji, Tao Fu, Ziyu Jia, Yinan Zhang and Xiaojiang Wu

    Citation: BMC Cancer 2021 21:216

    Content type: Research article

    Published on:

  43. Advances in curative treatment for breast, colorectal, NSCLC and prostate cancer have led to improvements in cancer survival. Cancer treatment and recovery time can vary depending on the recommended modalities...

    Authors: Selina K. Wong, Jeremy Hamm, Aria Shokoohi, Colleen E. McGahan and Cheryl Ho

    Citation: BMC Cancer 2021 21:215

    Content type: Research article

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  44. The outcomes of immediate autologous breast reconstruction (IABR) after partial mastectomy followed by postoperative radiotherapy (RT) in terms of aesthetics, treatment-related complications, and local control...

    Authors: Shu-Ling Zhang, Jun Song, Yan-Ru Wang, Yi-Jia Guo, Jian-Zhu Zhao, Li Sun, Le-Tian Huang, Jie-Tao Ma and Cheng-Bo Han

    Citation: BMC Cancer 2021 21:214

    Content type: Research article

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  45. Information regarding response to past treatments may provide clues concerning the classes of drugs most or least likely to work for a particular metastatic or neoadjuvant early stage breast cancer patient. Ho...

    Authors: Aleksandra K. Olow, Laura van ’t Veer and Denise M. Wolf

    Citation: BMC Cancer 2021 21:212

    Content type: Research article

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  46. Meningiomas are common brain tumours that are usually defined by benign clinical course. However, some meningiomas undergo a malignant transformation and recur within a short time period regardless of their Wo...

    Authors: Waseem Masalha, Karam Daka, Jakob Woerner, Nils Pompe, Stefan Weber, Daniel Delev, Marie T. Krüger, Oliver Schnell, Jürgen Beck, Dieter Henrik Heiland and Juergen Grauvogel

    Citation: BMC Cancer 2021 21:211

    Content type: Research article

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  48. There is evidence to consider that the tumor microenvironment (TME) composition associates with antitumor immune response, and may predict the outcome of various non-Hodgkin lymphoma subtypes. However, in the ...

    Authors: Guilherme Rossi Assis-Mendonça, André Fattori, Rafael Malagoli Rocha, Gustavo Jacob Lourenço, Márcia Torresan Delamain, Suely Nonogaki, Vladmir Cláudio Cordeiro de Lima, Gisele Wally Braga Colleoni, Cármino Antonio de Souza, Fernando Augusto Soares, Carmen Silvia Passos Lima and José Vassallo

    Citation: BMC Cancer 2021 21:209

    Content type: Research article

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  49. Lung cancer is most common among older individuals. However, polypharmacy and comorbidities, which are also more common in older individuals, can limit treatment options. Previous studies suggest that afatinib...

    Authors: Yuji Minegishi, Ou Yamaguchi, Shunichi Sugawara, Shoichi Kuyama, Satoshi Watanabe, Kazuhiro Usui, Masahide Mori, Osamu Hataji, Toshihiro Nukiwa, Satoshi Morita, Kunihiko Kobayashi and Akihiko Gemma

    Citation: BMC Cancer 2021 21:208

    Content type: Research article

    Published on:

  50. Colorectal cancer (CRC) is one of the most common cancers worldwide; it is the fourth leading cause of death in the world and the third in Brazil. Mutations in the APC, DCC, KRAS and TP53 genes have been associat...

    Authors: Aline Simoneti Fonseca, Anelisa Ramão, Matheus Carvalho Bürger, Jorge Estefano Santana de Souza, Dalila Lucíola Zanette, Greice Andreotti de Molfetta, Luiza Ferreira de Araújo, Rafaela de Barros e Lima Bueno, Graziela Moura Aguiar, Jessica Rodrigues Plaça, Cleidson de Pádua Alves, Anemari Ramos Dinarte dos Santos, Daniel Onofre Vidal, Gyl Eanes Barros Silva, Rodrigo Alexandre Panepucci, Fernanda Maris Peria…

    Citation: BMC Cancer 2021 21:207

    Content type: Research article

    Published on:

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