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Characteristics
|
Univariate analysis
|
Multivariate analysis
|
|---|
|
SHR(95%CI)
|
P Value
|
SHR(95%CI)
|
P Value
|
|---|
|
Age
|
1.372 (1.221–1.541)
|
0
|
1.05 (1.029–1.071)
|
0
|
|
Gender
|
|
Female
|
Ref
| | | |
|
Male
|
1.034 (0.908–1.179)
|
0.612
| | |
|
KFI
|
|
< 2
|
Ref
| |
Ref
| |
|
≥ 2
|
1.389 (1.087–1.776)
|
0.009
|
1.706 (1.109–2.624)
|
0.015
|
|
Smoking
|
|
No
|
Ref
| | | |
|
Yes
|
1.284 (0.904–1.824)
|
0.163
| | |
|
pT
| |
0
| |
0.004
|
|
T1
|
Ref
| |
Ref
| |
|
T2
|
2.317 (1.424–3.771)
|
0.001
|
3.122 (1.252–7.782)
|
0.015
|
|
T3
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2.869 (1.79–4.598)
|
0
|
5.073 (2.077–12.392)
|
0
|
|
T4
|
4.317 (2.728–6.831)
|
0
|
4.428 (1.762–11.129)
|
0.002
|
|
pN
| |
0.073
| |
.625
|
|
N0
|
Ref
| |
Ref
| |
|
N1
|
0.641 (0.445–0.924)
|
0.017
|
0.871 (0.451–1.68)
|
0.68
|
|
N2
|
0.825 (0.618–1.101)
|
0.192
|
1.127 (0.648–1.96)
|
0.671
|
|
N3
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1.078 (0.656–1.773)
|
0.766
|
1.575 (0.626–3.965)
|
0.335
|
|
AJCC Stage
|
|
III
|
Ref
| |
Ref
| |
|
IV
|
1.728 (1.413–2.113)
|
0
|
0.750 (0.513–1.095)
|
0.136
|
|
Perineural invasion
|
|
No
|
Ref
| | | |
|
Yes
|
1.225 (0.844–1.777)
|
0.285
| | |
|
Tumor differentation
| |
0.235
| | |
|
Well differentiated
|
Ref
| | | |
|
Moderately differentiated
|
1.774 (0.627–5.016)
|
0.28
| | |
|
Poorly differentiated
|
2.252 (0.61–8.315)
|
0.223
| | |
|
Depth of tumor invasion
|
|
< 20 mm
|
Ref
| | | |
|
≥ 20 mm
|
2.298 (0.537–9.834)
|
0.262
| | |
|
Number of Positive Nodes
| |
.009
| |
0.009
|
|
0
|
Ref
| |
Ref
| |
|
1–2
|
1.564 (1.076–2.272)
|
0.019
|
1.432 (1.003–2.044)
|
0.048
|
|
3–4
|
2.079 (1.307–3.308)
|
0.002
|
1.679 (1.097–2.569)
|
0.017
|
|
≥ 5
|
2.487 (1.572–3.935)
|
0.0001
|
2.413 (1.349–4.318)
|
0.003
|
|
Lymphovascular invasion (%)
|
|
No
|
Ref
| | | |
|
Yes
|
2.672 (0.639–11.172)
|
0.178
| | |
|
Primary Tumor Site
|
|
Tongue
|
Ref
| | | |
|
Floor of mouth
|
1.815 (0.593–5.55)
|
0.296
| | |
|
Other
|
1.865 (0.775–4.483)
|
0.164
| | |
|
Extracapsular extension
|
|
No
|
Ref
| | | |
|
Yes
|
1.866 (0.775–4.494)
|
0.164
| | |
|
Bone invasion
|
|
No
|
Ref
| | | |
|
Yes
|
1.689 (0.789–3.614)
|
0.177
| | |
|
Safety Margins
|
|
< 5 mm
|
Ref
| | | |
|
≥ 5 mm
|
1.699 (0.772–3.74)
|
0.188
| | |
|
SII
|
|
< 535.5
|
Ref
| |
Ref
| |
|
≥ 535.5
|
2.732 (1.149–6.498)
|
0.023
|
2.214 (1.289–3.805)
|
0.004
|
|
NLR
|
|
< 2.8
|
Ref
| |
Ref
| |
|
≥ 2.8
|
1.164 (1.022–1.326)
|
0.022
|
1.502 (0.729–3.096)
|
0.27
|
|
PLR
|
|
< 162.5
|
Ref
| |
Ref
| |
|
≥ 162.5
|
1.861 (1.048–3.304)
|
0.034
|
2.246 (0.732–6.885)
|
0.157
|
- Abbreviations: AJCC American Joint Committee on Cancer, KFI Kaplan-Feinstein index, NLR neutrophil-lymphocyte ratio, PLR platelet–lymphocyte ratio, SII systematic immune-inflammation index
