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Characteristics
|
Univariate analysis
|
P Value
|
Multivariate analysis
|
P Value
|
|---|
|
HR(95%CI)
|
HR(95%CI)
|
|---|
|
Gender
|
|
Female
|
Ref
| | | |
|
Male
|
1.034 (0.908–1.179)
|
0.612
| | |
|
Age
|
1.024 (1.014–1.035)
|
< 0.001
|
1.023 (1.012–1.033)
|
< 0.001
|
|
KFI
|
|
< 2
|
Ref
| |
Ref
| |
|
≥ 2
|
1.389 (1.087–1.776)
|
0.009
|
1.458 (1.137–1.871)
|
0.003
|
|
Smoking
|
|
No
|
Ref
| | | |
|
Yes
|
1.284 (0.904–1.824)
|
0.163
| | |
|
pT
| |
< 0.001
| |
< 0.001
|
|
T1
|
Ref
| |
Ref
| |
|
T2
|
2.317 (1.424–3.771)
|
0.001
|
2.128 (1.303–3.477)
|
0.003
|
|
T3
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2.869 (1.79–4.598)
|
0
|
3.157 (1.945–5.124)
|
0
|
|
T4
|
4.317 (2.728–6.831)
|
0
|
4.316 (2.674–6.966)
|
0
|
|
pN
| |
.073
| |
.065
|
|
N0
|
Ref
| |
Ref
| |
|
N1
|
0.641 (0.445–0.924)
|
0.017
|
1.031 (0.701–1.517)
|
0.876
|
|
N2
|
0.825 (0.618–1.101)
|
0.192
|
1.358 (0.99–1.864)
|
0.058
|
|
N3
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1.078 (0.656–1.773)
|
0.766
|
1.685 (1.01–2.811)
|
0.046
|
|
AJCC Stage
|
|
III
|
Ref
| |
Ref
| |
|
IV
|
1.526 (1.863–1.251)
|
< 0.001
|
1.358 (0.99–1.864)
|
0.058
|
|
Perineural invasion
|
|
No
|
Ref
| | | |
|
Yes
|
1.428 (0.778–2.618)
|
0.250
| | |
|
Tumor differentation
| |
0.224
| | |
|
Well differentiated
|
Ref
| | | |
|
Moderately differentiated
|
1.385 (0.856–2.241)
|
0.184
| | |
|
Poorly differentiated
|
2.581 (0.452–14.724)
|
0.286
| | |
|
Depth of tumor invasion
|
|
< 20 mm
|
Ref
| | | |
|
≥ 20 mm
|
1.385 (0.856–2.241)
|
0.184
| | |
|
Number of Positive Nodes
| |
0.002
| |
0.009
|
|
0
|
Ref
| |
Ref
| |
|
1–2
|
1.483 (1.112–1.979)
|
0.007
|
1.357 (1.013–1.819)
|
0.041
|
|
3–4
|
1.725 (1.238–2.402)
|
0.001
|
1.549 (1.106–2.171)
|
0.011
|
|
≥ 5
|
1.782 (1.203–2.64)
|
0.004
|
1.786 (1.202–2.653)
|
0.004
|
|
Lymphovascular invasion (%)
|
|
No
|
Ref
| | | |
|
Yes
|
2.581 (0.452–14.724)
|
0.286
| | |
|
Primary Tumor Site
| |
0.245
| | |
|
Tongue
|
Ref
| | | |
|
Floor of mouth
|
2.625 (0.726–9.486)
|
0.141
| | |
|
Other
|
1.306 (0.939–1.817)
|
0.113
| | |
|
Extracapsular extension
|
|
No
|
Ref
| | | |
|
Yes
|
2.377 (0.583–9.689)
|
0.227
| | |
|
Bone invasion
|
|
No
|
Ref
| | | |
|
Yes
|
1.244 (0.887–1.743)
|
0.206
| | |
|
Safety Margins
|
|
< 5 mm
|
Ref
| | | |
|
≥ 5 mm
|
1.397 (0.766–2.547)
|
0.276
| | |
|
SII
| | | | |
|
< 535.5
|
Ref
| |
Ref
| |
|
≥ 535.5
|
1.724 (1.354–2.194)
|
< 0.001
|
1.599 (1.25–2.047)
|
< 0.001
|
|
NLR
|
|
< 2.8
|
Ref
| |
Ref
| |
|
≥ 2.8
|
1.774 (1.09–2.885)
|
0.021
|
2.243 (0.751–6.704)
|
0.148
|
|
PLR
|
|
< 162.5
|
Ref
| |
Ref
| |
|
≥ 162.5
|
2.472 (1.127–5.424)
|
0.024
|
1.204 (0.854–1.699)
|
0.289
|
- Abbreviations: AJCC American Joint Committee on Cancer, KFI Kaplan-Feinstein index, NLR neutrophil-lymphocyte ratio, PLR platelet–lymphocyte ratio, SII systematic immune-inflammation index
