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|
Characteristics
|
Training cohort(n = 201)
|
Validation cohort(n = 68)
|
P Value
|
|---|
|
Gender
| | |
0.639
|
|
Female
|
50 (24.9)
|
15 (22.1)
| |
|
Male
|
151 (75.1)
|
53 (77.9)
| |
|
Age
|
62.7 ± 11.6
|
62.8 ± 11.9
|
0.956
|
|
KFI
| | |
0.257
|
|
< 2
|
125 (62.19)
|
37 (54.41)
| |
|
≥ 2
|
76 (37.81)
|
31 (45.59)
| |
|
Smoking
| | |
0.679
|
|
No
|
121 (60.2)
|
39 (57.35)
| |
|
Yes
|
80 (39.8)
|
29 (42.65)
| |
|
pT
| | |
0.359
|
|
T1
|
41 (20.4)
|
12 (17.65)
| |
|
T2
|
63 (31.34)
|
21 (30.88)
| |
|
T3
|
54 (26.87)
|
15 (22.06)
| |
|
T4
|
43 (21.39)
|
20 (29.41)
| |
|
pN
| | |
0.259
|
|
N0
|
31 (15.42)
|
9 (13.24)
| |
|
N1
|
53 (26.37)
|
14 (20.59)
| |
|
N2
|
110 (54.73)
|
40 (58.82)
| |
|
N3
|
7 (3.48)
|
5 (7.35)
| |
|
AJCC Stage
| | |
0.544
|
|
III
|
61 (30.3)
|
18 (26.5)
| |
|
IV
|
140 (69.7)
|
50 (73.5)
| |
|
Perineural invasion
| | |
0.931
|
|
No
|
120 (59.7)
|
41 (60.3)
| |
|
Yes
|
81 (40.3)
|
27 (39.7)
| |
|
Tumor differentiation
| | |
0.640
|
|
Well differentiated
|
87 (43.3)
|
25 (36.8)
| |
|
Moderately differentiated
|
51 (25.4)
|
19 (27.9)
| |
|
Poorly differentiated
|
63 (31.3)
|
24 (35.3)
| |
|
Depth of tumor invasion
| | |
0.268
|
|
< 20 mm
|
127 (63.2)
|
48 (70.6)
| |
|
≥ 20 mm
|
74 (36.8)
|
20 (29.4)
| |
|
Number of Positive Nodes
| | |
0.648
|
|
0
|
84 (41.79)
|
31 (45.6)
| |
|
1–2
|
58 (28.86)
|
21 (30.9)
| |
|
3–4
|
34 (16.92)
|
9 (13.2)
| |
|
≥ 5
|
25 (12.44)
|
7 (10.3)
| |
|
Lymphovascular invasion (%)
| | |
0.189
|
|
No
|
41 (20.4)
|
9 (13.24)
| |
|
Yes
|
160 (79.6)
|
59 (86.76)
| |
|
Primary Tumor Site
| | |
0.570
|
|
Tongue
|
69 (34.33)
|
21 (30.88)
| |
|
Floor of mouth
|
60 (29.85)
|
25 (36.76)
| |
|
Other
|
72 (35.82)
|
22 (32.35)
| |
|
Extracapsular extension
| | |
0.537
|
|
No
|
158 (78.61)
|
51 (75)
| |
|
Yes
|
43 (21.39)
|
17 (25)
| |
|
Bone invasion
| | |
0.366
|
|
No
|
119 (59.2)
|
36 (52.94)
| |
|
Yes
|
82 (40.8)
|
32 (47.06)
| |
|
Safety Margins
| | |
0.408
|
|
< 5 mm
|
45 (22.39)
|
12 (17.65)
| |
|
≥ 5 mm
|
156 (77.61)
|
56 (82.35)
| |
|
SII
| | |
0.580
|
|
< 535.5
|
120 (59.7)
|
38 (55.88)
| |
|
≥ 535.5
|
81 (40.3)
|
30 (44.12)
| |
|
NLR
| | |
0.480
|
|
< 2.8
|
125 (62.19)
|
39 (57.35)
| |
|
≥ 2.8
|
76 (37.81)
|
29 (42.65)
| |
|
PLR
| | |
0.761
|
|
< 162.5
|
114 (56.72)
|
40 (58.82)
| |
|
≥ 162.5
|
87 (43.28)
|
28 (41.18)
| |
- Abbreviations: AJCC American Joint Committee on Cancer, KFI Kaplan-Feinstein index, NLR neutrophil-lymphocyte ratio, PLR platelet–lymphocyte ratio, SII systematic immune-inflammation index
