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Table 1 Hallmark pathways differentially expressed ssGSEA scores (FDR < 0.10) between concurrent RB1 and TP53 genomically altered and DWT (Wilcoxon rank sum test, two-sided)

From: RB1 and TP53 co-mutations correlate strongly with genomic biomarkers of response to immunity checkpoint inhibitors in urothelial bladder cancer

Hallmark pathways Regulation FDR
E2F_TARGETS UP 2.85E-16
G2M_CHECKPOINT UP 2.00E-14
MITOTIC_SPINDLE UP 2.52E-13
SPERMATOGENESIS UP 3.65E-10
NOTCH_SIGNALING DOWN 1.31E-09
MYC_TARGETS_V1 UP 1.87E-09
ADIPOGENESIS DOWN 7.90E-07
PANCREAS_BETA_CELLS UP 1.27E-06
UV_RESPONSE_UP UP 1.26E-05
DNA_REPAIR UP 2.85E-05
P53_PATHWAY DOWN 4.67E-05
UNFOLDED_PROTEIN_RESPONSE UP 4.77E-05
MTORC1_SIGNALING UP 0.00025
XENOBIOTIC_METABOLISM DOWN 0.00037
PEROXISOME DOWN 0.00085
FATTY_ACID_METABOLISM DOWN 0.00222
BILE_ACID_METABOLISM DOWN 0.023
ANDROGEN_RESPONSE DOWN 0.028
OXIDATIVE_PHOSPHORYLATION DOWN 0.028
REACTIVE_OXIGEN_SPECIES_PATHWAY DOWN 0.032
MYC_TARGETS_V2 UP 0.034
GLYCOLYSIS UP 0.051
ALLOGRAFT_REJECTION UP 0.058
INTERFERON_GAMMA_RESPONSE UP 0.060
TGF_BETA_SIGNALING DOWN 0.065
MYOGENESIS DOWN 0.075
INTERFERON_ALPHA_RESPONSE UP 0.075
INFLAMMATORY_RESPONSE UP 0.078
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BMC Cancer

ISSN: 1471-2407

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