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a
Grade 0
Grade 1
Grade 2
Grade 3
Grade 4
TRG
1
14
45
50
19
Acute toxicity
Skin
50
50
22
10
0
Bladder
63
55
9
4
1
Rectum
18
65
31
16
2
Small bowel
51
54
18
5
4
Late toxicity
Skin
110
16
0
0
0
Bladder
105
4
2
14
1
Rectum
88
12
19
2
5
b
MN/BNL
NPB/BNL
3Gy in vitro
End RCT (50.4Gy)
3 Gy in vitro
End RCT (50.4Gy)
Kendall’s τ [CI]
P
Kendall’s τ [CI]
P
Kendall’s τ [CI]
P
Kendall’s τ [CI]
P
TRG
0.09 [−0.04–0.19]
0.18
−0.02 [−0.13–0.10]
0.78
−0.06 [−0.16–0.07]
0.42
−0.12 [−0.21–0.02]
0.09
Acute toxicity
Skin
0.10 [−0.01–0.18]
0.13
0.04 [−0.08–0.14]
0.56
0.00 [− 0.12–0.12]
1.00
− 0.09 [− 0.18–0.04]
0.21
Bladder
− 0.01 [− 0.11–0.10]
0.88
0.06 [− 0.06–0.16]
0.36
0.09 [− 0.04–0.18]
0.21
0.04 [− 0.08–0.13]
0.61
Rectum
0.13 [0.00–0.21]
0.06
0.02 [− 0.11–0.14]
0.82
− 0.17 [− 0.25 - -0.02]
0.01
− 0.10 [− 0.20–0.03]
0.15
Small bowel
−0.07 [− 0.17–0.05]
0.28
0.02 [− 0.10–0.13]
0.77
0.04 [− 0.07–0.14]
0.56
0.09 [− 0.04–0.18]
0.21
Late toxicity
0.07 [− 0.06–0.17]
0.30
−0.03 [− 0.15–0.10]
0.67
−0.07 [− 0.16–0.06]
0.33
−0.04 [− 0.14–0.08]
0.61
Skin
0.00 [− 0.08–0.08]
1.00
−0.12 [− 0.13–0.01]
0.11
0.02 [− 0.07–0.09]
0.75
0.03 [− 0.06–0.09]
0.72
Bladder
−0.03 [− 0.10–0.07]
0.73
0.01 [− 0.09–0.10]
0.89
−0.10 [− 0.014–0.03]
0.17
−0.03 [− 0–09 - 0.06]
0.68
Rectum
0.06 [− 0.06–0.14]
0.40
−0.10 [− 0.17–0.03]
0.18
0.04 [− 0.07–0.12]
0.57
0.02 [− 0.09–0.11]
0.83
TRG tumor regression grading, RCT radiochemotherapy; MN: micronuclei, BNL binuclear lymphocytes, NPB nucleoplasmatic bridges
